When the variable to be modeled is categorical, on the other hand, the available graphical methods are less informative and/or more complicated to use and the modeler needs to rely more heavily on statistical significance assessment in the model development. The latter is usually the likelihood ratio test (LR). Journal of Pharmacokinetics and Pharmacodynamics ( IF 2.745), Pub Date : , DOI: 10.1023/b:9 Ulrika Wählby,Katalin Matolcsi,Mats O Karlsson,E Niclas Jonsson The development of non-linear mixed pharmacokinetic/pharmacodynamic models for continuous variables is usually guided by graphical assessment of goodness of fit and statistical significance criteria. Evaluation of type I error rates when modeling ordered categorical data in NONMEM.
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